Subvolts take AI agents need knowledge engines, not just databases, for efficient machine-to-machine interaction. May 5, 2026
For you
Developers
Learn how to build more efficient agentic applications by rethinking data storage and reasoning integration.
Business
Understand how new AI infrastructure can improve accuracy, performance, and reduce costs for automated systems.
Hype note
3/5Notable

This episode features the CEO of a key AI infrastructure company discussing a new product and a fundamental shift in AI architecture.

From Vector Databases to Knowledge Engines: The Next Layer of AI

46 min Interview Hosts: a16z
0:0046:28

Audio streams from a16z. Your place is remembered on this device.

From Subvolts

Summary and analysis by Subvolts editorial, AI-assisted.

Summary

Peter Levine interviews Ash Ashutosh, CEO of Pinecone, about the launch of Nexus. They discuss the shift from vector databases to knowledge engines as AI agents become primary software users. The conversation covers why traditional retrieval systems fail for machine-to-machine interactions and how moving reasoning closer to data improves performance, accuracy, and cost.

Explained simply

Imagine AI programs acting like people, using software. This episode explains why current ways of finding information for these AI agents are slow. It introduces a new idea where AI can think about information right where it's stored, making everything faster and cheaper.

Why listen

This episode is for developers and product leaders building AI agentic applications. It explains the limitations of current retrieval systems for machine-to-machine communication and introduces Pinecone's new approach with Nexus. Listeners learn how optimizing agent workflows by integrating reasoning with data storage can significantly boost efficiency and reduce costs, a critical consideration as frontier labs like OpenAI and Google Gemini push agent capabilities.

On the mic
  • Hosta16z
  • GuestAsh AshutoshCEO, Pinecone
About
Key facts
  • Guest: Ash Ashutosh, CEO of Pinecone
  • Title: From Vector Databases to Knowledge Engines: The Next Layer of AI
  • Show: AI + a16z
  • Length: 46 minutes
  • Product Launch: Pinecone Nexus
Show notes from a16z

Peter Levine speaks with Ash Ashutosh, CEO of Pinecone, about the launch of Nexus and the shift from vector databases to knowledge engines. As agents become the primary users of software, they discuss why traditional retrieval systems break down and how AI systems need to evolve to support machine-to-machine interactions.

The conversation explores how agents currently spend most of their time retrieving and reasoning over data, why that approach is inefficient, and how moving reasoning closer to the data can dramatically improve performance, accuracy, and cost. Ash also explains how Pinecone is rethinking the stack for agentic applications, introducing new abstractions, query languages, and developer workflows.

 

Resources:

Follow Ash Ashutosh on X: https://x.com/ashashutosh

Follow Peter Levine on LinkedIn: https://www.linkedin.com/in/peter-levine-681386172/

 

Check out everything a16z is doing with artificial intelligence here, including articles, projects, and more podcasts.

 


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Jargon decoded
vector databases
Ash Ashutosh
Databases that store information as numerical lists, useful for finding similar items.
knowledge engines
Ash Ashutosh
Advanced systems that not only store information but also understand and reason with it.
agents
Ash Ashutosh
Software programs designed to perform tasks autonomously, often interacting with other software.
retrieval systems
Ash Ashutosh
Systems that find and fetch specific information from a larger dataset.
Published
Show
AI + a16z · a16z
Length
46 min
Companies
OpenAI, Google
Products
Nexus
Summary by
Subvolts, using an AI model (how we work). Spotted a mistake? Tell us.

Questions people ask

Why are traditional retrieval systems insufficient for AI agents?
Traditional systems break down as agents become the primary users of software, requiring more direct machine-to-machine interactions that current retrieval methods struggle to support efficiently.
What is the benefit of moving reasoning closer to data?
Moving reasoning closer to the data can dramatically improve performance, accuracy, and reduce costs for AI systems.

Page generated Oct 19, 2026. Summaries are Subvolts' own; the audio, artwork and notes belong to a16z.