No Priors
Founders and investors on where AI money and products are going next.
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Redefining Chip Architecture with Arm CEO Rene Haas
WithRene Haas
Rethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen Stein
WithOfir Ehrlich, Gonen Stein
All 51 episodes

Revolutionizing Cybersecurity and AI-Driven Science with OpenAI President Greg Brockman
OpenAI's president details AI's breakthroughs in science and productivity, plus cybersecurity needs.
HostsSarah Guo, Elad GilGuestsGreg Brockman (President, OpenAI)

Beam: The Great American Open Model with ReflectionAI Co-Founder and CEO Misha Laskin
Open models like Beam could capture most token demand and accelerate discovery, challenging closed systems.
HostsSarah Guo, Elad GilGuestsMisha Laskin (Co-Founder and CEO, ReflectionAI)

The Future of Frontier Model Architectures with Walter Goodwin, Fractile Founder and CEO
Fractile's CEO explains how new AI chip designs accelerate model performance and market impact.
HostsSarah Guo, Elad GilGuestsWalter Goodwin (Founder and CEO, Fractile)

Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee
AI can reshape incumbents from the inside out, not just replace them.
HostsSarah Guo, Elad GilGuestsMichael Lee (Co-founder and CEO, Sequence Holdings)

Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon
Diffusion models offer a path to more efficient AI inference, outperforming current LLMs on hardware.
HostsSarah Guo, Elad GilGuestsStefano Ermon (Co-founder and CEO, Inception)

Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong
Coinbase CEO Brian Armstrong discusses AI, agentic finance, and longevity research.
HostsSarah Guo, Elad GilGuestsBrian Armstrong (CEO, Coinbase)

Redefining Chip Architecture with Arm CEO Rene Haas
Arm's CEO details how their chips power AI and the future of computing hardware.
HostsSarah Guo, Elad GilGuestsRene Haas (CEO, Arm)

Rethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen Stein
Unlock your enterprise data's AI potential with Eon's secure data foundation.
HostsSarah Guo, Elad GilGuestsOfir Ehrlich (CEO / Co-Founder, Eon), Gonen Stein (President / Co-Founder, Eon)

From Restoring Sight to Reimagining the Brain, with Max Hodak
Neural implants could restore sight and upgrade humans, drawing parallels to AI's understanding of intelligence.
HostsSarah Guo, Elad GilGuestsMax Hodak (CEO, Science Corporation)

What Chess.com Teaches US About Superhuman Capabilities, with CEO Erik Allebest
Chess.com's CEO shares how AI and community building keep a classic game thriving.
HostsSarah Guo, Elad GilGuestsErik Allebest (CEO, Chess.com)

Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad
Founders grapple with AI's pace, market shifts, and the race to build trillion-dollar companies.
HostsSarah Guo, Elad Gil

Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
Netic's AI platform automates essential services, showing AI's real-world impact beyond frontier labs.
HostsSarah Guo, Elad GilGuestsMelisa Tokmak (Founder and CEO, Netic)

Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
DoorDash uses AI and robots to reinvent delivery, tackling real-world challenges with human couriers.
HostsSarah Guo, Elad GilGuestsAndy Fang (Co-founder, DoorDash), Stanley Tang (Co-founder, DoorDash)

Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel
Booking.com's CEO shares how AI transforms travel planning and customer service.
HostsSarah Guo, Elad GilGuestsGlenn Fogel (CEO, Booking Holdings)

How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
Valar Atomics is building real nuclear reactors, not just designs, to unlock abundant energy.
HostsSarah Guo, Elad GilGuestsIsaiah Taylor (Founder and CEO, Valar Atomics)

Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
AI benchmarks are broken; test-time compute reveals true model power.
HostsSarah Guo, Elad GilGuestsNoam Brown (Research Scientist, OpenAI)

Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
Intel's CEO shares his plan to revive the chip giant and focus on AI hardware.
HostsSarah Guo, Elad GilGuestsLip-Bu Tan (CEO, Intel)

Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
Biohub uses AI to model biology and design proteins, aiming to cure disease.
HostsSarah Guo, Elad GilGuestsMark Zuckerberg (Co-founder, Biohub), Priscilla Chan (Co-founder, Biohub), Alex Rives (Head of Science, Biohub)

We Need An Ecosystem in AI, And Every Company Can Win A Place In It
Microsoft's CEO outlines the future of AI platforms and enterprise adoption.
HostsSarah Guo, Elad GilGuestsSatya Nadella (Chairman and CEO, Microsoft)

Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
Secure autonomous AI agents with an enterprise control plane that balances performance, cost, and reliability.
HostsSarah Guo, Elad GilGuestsMaxim Bar Kogan (founder and CEO, Onyx Securities)

The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
Cerebras's wafer-scale AI chips powered a $63B IPO and an OpenAI deal.
HostsSarah Guo, Elad GilGuestsAndrew Feldman (Founder and CEO, Cerebras)

Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
US strategy to control the AI supply chain through international partnerships and industrial policy.
HostsSarah Guo, Elad GilGuestsJacob Helberg (US Under Secretary of State for Economic Affairs, US Department of State)

Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
AI is now buying and transforming entire companies, not just selling software.
HostsSarah Guo, Elad GilGuestsAlexander Taubman (CEO, Long Lake Management)

Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
Inference infrastructure is the new frontier, with custom models driving demand.
HostsSarah Guo, Elad GilGuestsTuhin Srivastava (CEO, Baseten)

SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
SAP's CTO explains how to integrate AI into core business systems for real-world impact.
HostsSarah Guo, Elad GilGuestsPhilipp Herzig (Chief Technology Officer, SAP)

Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
AI must serve people, not replace ambition, says ServiceNow CEO Bill McDermott.
HostsSarah Guo, Elad GilGuestsBill McDermott (Chairman and CEO, ServiceNow)

The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
AI agents need a financial operating system; Circle's Arc Blockchain aims to be it.
HostsSarah Guo, Elad GilGuestsJeremy Allaire (Co-founder and CEO, Circle)

AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
AI is now engineering atoms: learn how LLMs orchestrate physical experiments for new materials.
HostsSarah Guo, Elad GilGuestsLiam Fedus (Co-Founder, Periodic Labs)

Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
AI can now autonomously conduct research. Karpathy explains how.
HostsSarah Guo, Elad GilGuestsAndrej Karpathy

From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Notion builds AI agents that code and integrate themselves, shifting work from humans to agent management.
HostsSarah Guo, Elad GilGuestsSimon Last (Co-Founder, Notion)

How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
AI's infrastructure buildout hinges on creative financing, not just model prowess.
HostsSarah Guo, Elad GilGuestsNeil Tiwari (Managing Director, Magnetar Capital)

From SaaS to AI-First: How Companies Are Reshaping Innovation
AI is reshaping software business models, impacting sales, development, and market concentration.
HostsSarah Guo, Elad Gil

Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Rivian's CEO explains their AI-driven vehicle architecture and the future of autonomous driving.
HostsSarah Guo, Elad GilGuestsRJ Scaringe (Founder and CEO, Rivian)

Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
Roblox CEO discusses AI's role in building virtual worlds and intuitive NPCs.
HostsSarah Guo, Elad GilGuestsDave Baszucki (CEO, Roblox)

Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
Pause life's clock: explore cryopreservation's potential for medicine and longevity.
HostsSarah Guo, Elad GilGuestsLaura Deming (CEO and co-founder, Until)

No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
Durable software hinges on platforms, not replaceable products, even with AI's rise.
HostsSarah Guo, Elad GilGuestsCJ Desai (President & CEO, MongoDB)

AI and the Future of Warfare with US Under Secretary of War Emil Michael
See how the US military uses generative AI for national security and industrial base rebuilding.
HostsSarah Guo, Elad GilGuestsEmil Michael (Under Secretary of War for Research and Engineering, United States Department of War)

NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
NVIDIA's CEO explains why AI's growth is inevitable, not a bubble, and how it will reshape industries.
HostsSarah Guo, Elad GilGuestsJensen Huang (President, Founder, and CEO, NVIDIA)

The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
AI's 2026 forecast covers models, robotics, IPOs, and consumer agents, with industry leader insights.
HostsSarah Guo, Elad GilGuestsJensen Huang (Founder/CEO, NVIDIA), Arvind Jain (Founder/CEO, Glean), Winston Weinberg (Founder/CEO, Harvey), Scott Wu (Founder/CEO, Cognition)

The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
Voice AI is becoming the ultimate interface, powering tutors, translation, and proactive agents.
HostsSarah Guo, Elad GilGuestsMati Staniszewski (co-founder, ElevenLabs)

Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
Legal AI transforms law firms with agents, boosting profitability and changing associate training.
HostsSarah Guo, Elad GilGuestsGabe Pereyra (President, Harvey)

Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
Home robots are closer than you think, driven by AI advances and new data collection methods.
HostsSarah Guo, Elad GilGuestsTony Zhao (Co-founder, Sunday Robotics), Cheng Chi (Co-founder, Sunday Robotics)

How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
AI agents can speed up biotech research and drug discovery, fixing a slow and costly process.
HostsSarah Guo, Elad GilGuestsSajith Wickramasekara (CEO, Benchling)

Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
Snowflake's CEO details their AI agent platform, transforming enterprise data management.
HostsSarah Guo, Elad GilGuestsSridhar Ramaswamy (CEO, Snowflake)

The Best of 2025 (So Far) with Sarah Guo and Elad Gil
AI's 2025 highlights from top minds, covering everything from spatial intelligence to superintelligence.
HostsSarah Guo, Elad GilGuestsWinston Weinberg (Harvey), Dr. Fei-Fei Li (World Labs), Brendan Foody (Mercor), Dan Hendrycks (Center for AI Safety)

Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
Warp's CEO explains how a smarter terminal will unlock AI agents for automated coding.
HostsSarah Guo, Elad GilGuestsZach Lloyd (CEO and Co-founder, Warp)

Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
AI's energy needs are straining the grid; Base Power aims to fix it by building power from the ground up.
HostsSarah Guo, Elad GilGuestsZach Dell (CEO and Co-Founder, Base Power)

Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
Build AI with emotional intelligence, not just smarts, for better human collaboration.
HostsSarah Guo, Elad GilGuestsEric Zelikman (founder, humans&)

The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
AI reshapes search, business, and cybersecurity, according to Palo Alto Networks CEO Nikesh Arora.
HostsSarah Guo, Elad GilGuestsNikesh Arora (CEO, Palo Alto Networks)

Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
AI can shorten the school day and boost learning by focusing on passion and incentives.
HostsSarah Guo, Elad GilGuestsJoe Liemandt (Principal, Alpha School)

AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
AI agents are replacing call centers, boosting business efficiency and changing customer service.
HostsSarah Guo, Elad GilGuestsJesse Zhang (CEO, Decagon)
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